PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

Stable Identifier
R-HSA-1676206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
early endosome membrane, cytosol
ReviewStatus
5/5
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PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
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At the early endosome membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Kraq et al. 2010, Arcaro et al. 2000) phosphorylates phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

Literature References
PubMed ID Title Journal Year
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J

Mol Cell Biol 2000
21081650 PI3KC2?, a class II PI3K, is required for dynamin-independent internalization pathways

Krag, C, Salcini, AE, Malmberg, EK

J Cell Sci 2010
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Output
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Catalyst Activity

1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A:Ca2+/Mg2+ [cytosol]

Physical Entity
PIK3C2A:Ca2+/Mg2+ [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005)
Orthologous Events
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Gallus gallus)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Rattus norvegicus)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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