Reactome | PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

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PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806249] phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity of PIKFYVE:VAC14:FIG4 [late endosome membrane]
category	transition
compartment	[Compartment:172574] late endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:12667426] RHEA:32955
dbId	1676020
displayName	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660517] Synthesis of PIPs at the late endosome membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1675910] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane - Homo sapiens [Reaction:R-HSA-1675795] PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806289] PI(3,5)P2 [late endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675790] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex [LiteratureReference:1460276] ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
orthologousEvent	[Reaction:R-GGA-1676020] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane - Gallus gallus [Reaction:R-SSC-1676020] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane - Sus scrofa [Reaction:R-BTA-1676020] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane - Bos taurus [Reaction:R-CFA-1676020] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane - Canis familiaris [Reaction:R-RNO-1676020] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane - Rattus norvegicus [Reaction:R-MMU-1676020] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806198] PI3P [late endosome membrane]
precedingEvent	[Reaction:R-HSA-1675910] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane - Homo sapiens [BlackBoxEvent:R-HSA-1676041] Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676020
summation	[Summation:1676038] At the late endosome membrane, the PAS complex, consisting o...

Referrals

(hasEvent)	[Pathway:R-HSA-1660517] Synthesis of PIPs at the late endosome membrane
(precedingEvent)	[Reaction:R-HSA-1675910] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane [Reaction:R-HSA-1675795] PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane