At the late endosome membrane, the PAS complex, consisting o...

created [InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId 1676038
displayName At the late endosome membrane, the PAS complex, consisting o...
modified [InstanceEdit:2063939] Williams, MG, 2012-01-18
schemaClass Summation
text At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).
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