PRLR activation

Stable Identifier
R-HSA-1671687
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
plasma membrane
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PRLR activation
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Ligand binding activates the PRLR, probably by causing a subtle conformational change (Broutin et al. 2010).

Literature References
PubMed ID Title Journal Year
20053995 Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2

Broutin, I, Jomain, JB, Tallet, E, van Agthoven, J, Raynal, B, Hoos, S, Kragelund, BB, Kelly, PA, Ducruix, A, England, P, Goffin, V

J Biol Chem 2010
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
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PRLR activation (Rattus norvegicus)
PRLR activation (Xenopus tropicalis)
Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-10-17)
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