Reactome | Signalling to RAS

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Signalling to RAS Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:167064] 2006-02-07 08:34:19
crossReference	[DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424
dbId	167044
displayName	Signalling to RAS
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-187687] Signalling to ERKs - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20313] Ras protein signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-167056] SHC binds to the activated TrkA receptor - Homo sapiens [Reaction:R-HSA-167019] SHC, complexed with TrkA, is tyrosine-phosphorylated - Homo sapiens [Reaction:R-HSA-167217] Phospho-Shc dissociates from the TrkA receptor - Homo sapiens [Reaction:R-HSA-5685366] GRB2-1:SOS1 binds p-Y-SHC - Homo sapiens [Reaction:R-HSA-5686071] GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS - Homo sapiens [Pathway:R-HSA-171007] p38MAPK events - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-09-30
literatureReference	[LiteratureReference:189686] Nerve growth factor signaling, neuroprotection, and neural repair
maxDepth	3
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signalling to RAS
orthologousEvent	[Pathway:R-DRE-167044] Signalling to RAS - Danio rerio [Pathway:R-PFA-167044] Signalling to RAS - Plasmodium falciparum [Pathway:R-DDI-167044] Signalling to RAS - Dictyostelium discoideum [Pathway:R-CEL-167044] Signalling to RAS - Caenorhabditis elegans [Pathway:R-DME-167044] Signalling to RAS - Drosophila melanogaster [Pathway:R-GGA-167044] Signalling to RAS - Gallus gallus [Pathway:R-XTR-167044] Signalling to RAS - Xenopus tropicalis [Pathway:R-SSC-167044] Signalling to RAS - Sus scrofa [Pathway:R-BTA-167044] Signalling to RAS - Bos taurus [Pathway:R-CFA-167044] Signalling to RAS - Canis familiaris [Pathway:R-RNO-167044] Signalling to RAS - Rattus norvegicus [Pathway:R-MMU-167044] Signalling to RAS - Mus musculus
precedingEvent	[Reaction:R-HSA-166544] TrkA receptor autophosphorylates - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-167044
summation	[Summation:187707] Signalling through Shc adaptor proteins appears to be identi...
updateTrackers	[UpdateTracker:9783386] Update Tracker - [Pathway:167044] Signalling to RAS - v56:[updateContainedPathway] [UpdateTracker:9784784] Update Tracker - [Pathway:167044] Signalling to RAS - v53:[add_removeHasEvent] [UpdateTracker:9790424] Update Tracker - [Pathway:167044] Signalling to RAS - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9789535] Update Tracker - [Pathway:167044] Signalling to RAS - v37:[removeHasEvent] [UpdateTracker:9791991] Update Tracker - [Pathway:167044] Signalling to RAS - v24:[updateContainedRLE] [UpdateTracker:9780773] Update Tracker - [Pathway:167044] Signalling to RAS - v62:[removeHasEvent] [UpdateTracker:9782442] Update Tracker - [Pathway:167044] Signalling to RAS - v59:[removeHasEvent] [UpdateTracker:9788964] Update Tracker - [Pathway:167044] Signalling to RAS - v39:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9779055] Update Tracker - [Pathway:167044] Signalling to RAS - v66:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783339] Update Tracker - [Pathway:167044] Signalling to RAS - v57:[updateIndirectRLE]

Referrals

(updatedInstance)

[UpdateTracker:9783386] Update Tracker - [Pathway:167044] Signalling to RAS - v56:[updateContainedPathway]
[UpdateTracker:9784784] Update Tracker - [Pathway:167044] Signalling to RAS - v53:[add_removeHasEvent]
[UpdateTracker:9790424] Update Tracker - [Pathway:167044] Signalling to RAS - v33:[addHasEvent, updateContainedRLE]
[UpdateTracker:9789535] Update Tracker - [Pathway:167044] Signalling to RAS - v37:[removeHasEvent]
[UpdateTracker:9791991] Update Tracker - [Pathway:167044] Signalling to RAS - v24:[updateContainedRLE]
[UpdateTracker:9780773] Update Tracker - [Pathway:167044] Signalling to RAS - v62:[removeHasEvent]
[UpdateTracker:9782442] Update Tracker - [Pathway:167044] Signalling to RAS - v59:[removeHasEvent]
[UpdateTracker:9788964] Update Tracker - [Pathway:167044] Signalling to RAS - v39:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9779055] Update Tracker - [Pathway:167044] Signalling to RAS - v66:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783339] Update Tracker - [Pathway:167044] Signalling to RAS - v57:[updateIndirectRLE]

(hasEvent)

[Pathway:R-HSA-187687] Signalling to ERKs

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