Reactome | TrkA receptor autophosphorylates

Schema > Reaction > Entries

TrkA receptor autophosphorylates Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198204] transmembrane receptor protein tyrosine kinase activity of beta-NGF dimer:TrkA receptor dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:166541] Jassal, Bijay, 2005-09-08
dbId	166544
displayName	TrkA receptor autophosphorylates
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-187042] TRKA activation by NGF - Homo sapiens
followingEvent	[Reaction:R-HSA-198732] STAT3 activation - Homo sapiens [Reaction:R-HSA-177491] Formation of clathrin-coated vesicle - Homo sapiens [Reaction:R-HSA-187697] TRKA recruits RIT and RIN - Homo sapiens [Reaction:R-HSA-169891] ARMS:Crk complex binds to active TrkA receptor - Homo sapiens [Pathway:R-HSA-167044] Signalling to RAS - Homo sapiens [BlackBoxEvent:R-HSA-190065] Activated TrkA receptor internalizes to endosomes - Homo sapiens [Reaction:R-HSA-167056] SHC binds to the activated TrkA receptor - Homo sapiens [Reaction:R-HSA-198211] Active TRKA binds IRS1/2 - Homo sapiens [Reaction:R-HSA-167674] Binding of PLCG1 to active TrkA receptor - Homo sapiens
inferredFrom	[Reaction:R-RNO-181812] Trk receptor autophosphorylates - Rattus norvegicus
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-166543] beta-NGF dimer:TrkA receptor dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TrkA receptor autophosphorylates
output	[Complex:R-HSA-166540] Activated TrkA receptor complex [plasma membrane] 10 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-166538] The bound receptor dimerizes - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166544
summation	[Summation:167061] NGF binding induces a conformational change in TRKA, which e...
updateTrackers	[UpdateTracker:9792262] Update Tracker - [Reaction:166544] TrkA receptor autophosphorylates - v22:[addCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792262] Update Tracker - [Reaction:166544] TrkA receptor autophosphorylates - v22:[addCatalystActivity, modifyText]
(precedingEvent)	[Reaction:R-HSA-198732] STAT3 activation [Reaction:R-HSA-177491] Formation of clathrin-coated vesicle [Reaction:R-HSA-187697] TRKA recruits RIT and RIN [Reaction:R-HSA-169891] ARMS:Crk complex binds to active TrkA receptor [Pathway:R-HSA-167044] Signalling to RAS [BlackBoxEvent:R-HSA-190065] Activated TrkA receptor internalizes to endosomes [Reaction:R-HSA-167674] Binding of PLCG1 to active TrkA receptor [Reaction:R-HSA-167056] SHC binds to the activated TrkA receptor [Reaction:R-HSA-198211] Active TRKA binds IRS1/2
(hasEvent)	[Pathway:R-HSA-187042] TRKA activation by NGF
(inferredTo)	[Reaction:R-RNO-181812] Trk receptor autophosphorylates