Signalling to RAS

Stable Identifier
R-HSA-167044
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Signalling to RAS
Click the image above or here to open this pathway in the Pathway Browser

Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.

Literature References
PubMed ID Title Journal Year
11520933 Nerve growth factor signaling, neuroprotection, and neural repair

Sofroniew, MV, Howe, CL, Mobley, WC

Annu Rev Neurosci 2001
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
Ras protein signal transduction (0007265)
Orthologous Events
Signalling to RAS (Bos taurus)
Signalling to RAS (Caenorhabditis elegans)
Signalling to RAS (Canis familiaris)
Signalling to RAS (Danio rerio)
Signalling to RAS (Dictyostelium discoideum)
Signalling to RAS (Drosophila melanogaster)
Signalling to RAS (Gallus gallus)
Signalling to RAS (Mus musculus)
Signalling to RAS (Plasmodium falciparum)
Signalling to RAS (Rattus norvegicus)
Signalling to RAS (Sus scrofa)
Signalling to RAS (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Cite Us!