Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP

Stable Identifier
R-HSA-166284
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
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Second, Thr387 in the activation loop is phosphorylated, leading to full enzymatic activity.
Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]

Physical Entity
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gillespie, ME  (2010-11-30)
Gay, NJ  (2006-04-24)
Napetschnig, J  (2012-11-16)
Created
de Bono, B  (2005-08-23)
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