IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]

Stable Identifier
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:Mal:activated TLR
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Jefferies, CA, O'Neill, LA, Mansell, AS, Bird, TA, Brint, E, Smith, DE, Gray, P, Sims, JE, Palsson-McDermott, EM, Bowie, AG, Harte, MT, Fitzgerald, KA, McMurray, D, Dunne, A, Brady, G

Nature 2001
19679662 Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases

Ruggiero, V, Gallo, G, Fantò, N, Loiarro, M, De Santis, R, Carminati, P, Sette, C

J Biol Chem 2009
20485341 Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling

Lo, YC, Lin, SC, Wu, H

Nature 2010
20400509 IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)

Brikos, C, Wesche, H, O'Neill, LA, Gray, P, Morrice, N, Strelow, A, Carpenter, S, Dunne, A

J. Biol. Chem. 2010
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