Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)

Stable Identifier
R-HSA-1655849
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The SCD gene is transcribed to yield mRNA (Li et al. 1994) and the mRNA is translated to yield protein. The SREBP1A (SREBF1A) and SREBP1C (SREBF1C) transcription factors bind the promoter of the SCD gene and activate transcription in response to low cellular cholesterol (Tabor et al. 1999, Bee et al. 2001).

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Summation

SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the Stearoyl CoA Desaturase 1 (SCD1) gene and enhance transcription (Shimano et al. 1996, Pai et al. 1998, Shimao et al. 1999, Tabor et al. 1999, Bene et al. 2001, reviewed in Horton et al. 2002).

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