Reactome | Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)

Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)

Stable Identifier

R-HSA-1655849

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, endoplasmic reticulum membrane

ReviewStatus

5/5

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Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)

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SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the Stearoyl CoA Desaturase 1 (SCD1) gene and enhance transcription (Shimano et al. 1996, Pai et al. 1998, Shimao et al. 1999, Tabor et al. 1999, Bene et al. 2001, reviewed in Horton et al. 2002). The SCD gene is transcribed to yield mRNA (Li et al. 1994) and the mRNA is translated to yield protein. The SREBP1A (SREBF1A) and SREBP1C (SREBF1C) transcription factors bind the promoter of the SCD gene and activate transcription in response to low cellular cholesterol (Tabor et al. 1999, Bee et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
10400691	Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 Tabor, DE, Kim, JB, Spiegelman, BM, Edwards, PA	J Biol Chem	1999
7909540	Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues Li, J, Ding, SF, Habib, NA, Fermor, BF, Wood, CB, Gilmour, RS	Int J Cancer	1994
11414710	Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol Bené, H, Lasky, D, Ntambi, JM	Biochem Biophys Res Commun	2001