Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)

Stable Identifier
R-HSA-1655849
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)
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SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the Stearoyl CoA Desaturase 1 (SCD1) gene and enhance transcription (Shimano et al. 1996, Pai et al. 1998, Shimao et al. 1999, Tabor et al. 1999, Bene et al. 2001, reviewed in Horton et al. 2002). The SCD gene is transcribed to yield mRNA (Li et al. 1994) and the mRNA is translated to yield protein. The SREBP1A (SREBF1A) and SREBP1C (SREBF1C) transcription factors bind the promoter of the SCD gene and activate transcription in response to low cellular cholesterol (Tabor et al. 1999, Bee et al. 2001).
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Regulator
SREBP1A,1C:SCD gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-28)
Reviewed
May, B  (2015-09-27)
Created
May, B  (2011-10-13)
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