Reactome | SREBP1A,1C,2 translocates to the nucleus

Schema > BlackBoxEvent > Entries

SREBP1A,1C,2 translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:1655770] May, B, 2011-09-28
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:1655841] May, B, 2011-10-13
dbId	1655831
displayName	SREBP1A,1C,2 translocates to the nucleus
edited	[InstanceEdit:1655770] May, B, 2011-09-28
eventOf	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Homo sapiens
followingEvent	[Reaction:R-HSA-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:11054] protein import into nucleus
input	[Complex:R-HSA-2065556] SREBP1A,1C,2:Importin beta-1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1368888] SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis [LiteratureReference:1655558] Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment [LiteratureReference:1655686] Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta [LiteratureReference:1655711] The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor [LiteratureReference:1655706] Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip [LiteratureReference:1655600] Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution [LiteratureReference:1655621] Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers [LiteratureReference:9717132] Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SREBP1A,1C,2 translocates to the nucleus SREBF1A,1C,2 translocates to the nucleus
orthologousEvent	[BlackBoxEvent:R-CEL-1655831] SREBP1A,1C,2 translocates to the nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-1655831] SREBP1A,1C,2 translocates to the nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-1655831] SREBP1A,1C,2 translocates to the nucleus - Gallus gallus [BlackBoxEvent:R-XTR-1655831] SREBP1A,1C,2 translocates to the nucleus - Xenopus tropicalis [BlackBoxEvent:R-DRE-1655831] SREBP1A,1C,2 translocates to the nucleus - Danio rerio [BlackBoxEvent:R-SSC-1655831] SREBP1A,1C,2 translocates to the nucleus - Sus scrofa [BlackBoxEvent:R-BTA-1655831] SREBP1A,1C,2 translocates to the nucleus - Bos taurus [BlackBoxEvent:R-RNO-1655831] SREBP1A,1C,2 translocates to the nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-1655831] SREBP1A,1C,2 translocates to the nucleus - Mus musculus
output	[Complex:R-HSA-2065543] SREBP1A,1C,2:Importin beta-1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2065550] SREBP1A,1C,2 binds Importin beta-1 - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2457630] Liang, Guosheng, 2012-08-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1655831
summation	[Summation:1655782] The N-terminal domain of SREBP1A,1C,2 (SREBF1A,1C,2) dimeriz...
updateTrackers	[UpdateTracker:9776146] Update Tracker - [BlackBoxEvent:1655831] SREBP1A,1C,2 translocates to the nucleus - v77:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776146] Update Tracker - [BlackBoxEvent:1655831] SREBP1A,1C,2 translocates to the nucleus - v77:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)
(precedingEvent)	[Reaction:R-HSA-2065539] SREBP1A,1C,2:Importin beta-1 dissociates

Cite Us!