Reactome | SREBP1A,1C,2 translocates to the nucleus

SREBP1A,1C,2 translocates to the nucleus

Stable Identifier

R-HSA-1655831

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Synonyms

SREBF1A,1C,2 translocates to the nucleus

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SREBP1A,1C,2 translocates to the nucleus

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The N-terminal domain of SREBP1A,1C,2 (SREBF1A,1C,2) dimerizes and is imported from the cytosol into the nucleus by importin-beta (Nagoshi et al. 1999, Nagoshi and Yoned 2001, Lee et al. 2003, Di Pardo et al. 2020). In the nucleus the dimers bind DNA (Parraga et al. 1998) and activate transcription (Datta and Osborne 2005).

Literature References

PubMed ID	Title	Journal	Year
8674110	Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment Sakai, J, Duncan, EA, Rawson, RB, Hua, X, Brown, MS, Goldstein, JL	Cell	1996
11283257	Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta Nagoshi, E, Yoneda, Y	Mol Cell Biol	2001
15550381	Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers Datta, S, Osborne, TF	J Biol Chem	2005
8156598	SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Wang, X, Sato, R, Brown, MS, Hua, X, Goldstein, JL	Cell	1994
9634703	Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution Párraga, A, Bellsolell, L, Ferré-D'Amaré, AR, Burley, SK	Structure	1998
31875875	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import Di Pardo, A, Monyror, J, Morales, LC, Kadam, V, Lingrell, S, Maglione, V, Wozniak, RW, Sipione, S	Hum Mol Genet	2020
14645851	The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor Lee, SJ, Sekimoto, T, Yamashita, E, Nagoshi, E, Nakagawa, A, Imamoto, N, Yoshimura, M, Sakai, H, Chong, KT, Tsukihara, T, Yoneda, Y	Science	2003
10397761	Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip Nagoshi, E, Imamoto, N, Sato, R, Yoneda, Y	Mol Biol Cell	1999