SREBP1A,1C,2 translocates to the nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
SREBF1A,1C,2 translocates to the nucleus
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The N-terminal domain of SREBP1A,1C,2 (SREBF1A,1C,2) dimerizes and is imported from the cytosol into the nucleus by importin-beta (Nagoshi et al. 1999, Nagoshi and Yoned 2001, Lee et al. 2003, Di Pardo et al. 2020). In the nucleus the dimers bind DNA (Parraga et al. 1998) and activate transcription (Datta and Osborne 2005).
Literature References
PubMed ID Title Journal Year
11283257 Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta

Yoneda, Y, Nagoshi, E

Mol Cell Biol 2001
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Brown, MS, Rawson, RB, Hua, X, Duncan, EA, Sakai, J, Goldstein, JL

Cell 1996
15550381 Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers

Osborne, TF, Datta, S

J Biol Chem 2005
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Brown, MS, Wang, X, Goldstein, JL, Hua, X, Sato, R

Cell 1994
9634703 Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution

Ferré-D'Amaré, AR, Párraga, A, Burley, SK, Bellsolell, L

Structure 1998
31875875 Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import

Morales, LC, Kadam, V, Sipione, S, Wozniak, RW, Monyror, J, Maglione, V, Di Pardo, A, Lingrell, S

Hum Mol Genet 2020
14645851 The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor

Chong, KT, Imamoto, N, Yoneda, Y, Sakai, H, Nakagawa, A, Yoshimura, M, Nagoshi, E, Tsukihara, T, Sekimoto, T, Lee, SJ, Yamashita, E

Science 2003
10397761 Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

Imamoto, N, Yoneda, Y, Nagoshi, E, Sato, R

Mol Biol Cell 1999
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