SREBP1A,1C,2 translocates to the nucleus

Stable Identifier
R-HSA-1655831
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
SREBF1A,1C,2 translocates to the nucleus
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The N-terminal domain of SREBP1A/1C/2 (SREBF1A/1C/2) dimerizes and is imported from the cytosol into the nucleus by importin-beta (Nagoshi et al. 1999, Nagoshi and Yoned 2001, Lee et al. 2003). In the nucleus the dimers bind DNA (Parraga et al. 1998) and activate transcription (Datta and Osborne 2005).

Literature References
PubMed ID Title Journal Year
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Sakai, J, Duncan, EA, Rawson, RB, Hua, X, Brown, MS, Goldstein, JL

Cell 1996
11283257 Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta

Nagoshi, E, Yoneda, Y

Mol Cell Biol 2001
15550381 Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers

Datta, S, Osborne, TF

J Biol Chem 2005
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Wang, X, Sato, R, Brown, MS, Hua, X, Goldstein, JL

Cell 1994
9634703 Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution

Párraga, A, Bellsolell, L, Ferré-D'Amaré, AR, Burley, SK

Structure 1998
14645851 The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor

Lee, SJ, Sekimoto, T, Yamashita, E, Nagoshi, E, Nakagawa, A, Imamoto, N, Yoshimura, M, Sakai, H, Chong, KT, Tsukihara, T, Yoneda, Y

Science 2003
10397761 Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

Nagoshi, E, Imamoto, N, Sato, R, Yoneda, Y

Mol Biol Cell 1999
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