Reactome | SREBP1A,1C,2:Importin beta-1 dissociates

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SREBP1A,1C,2:Importin beta-1 dissociates Show undefined attributes

authored	[InstanceEdit:2065547] May, B, 2012-01-23
catalystActivity	[CatalystActivity:9959904] importin-alpha family protein binding activity of RAN:GTP [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2065546] May, B, 2012-01-23
dbId	2065539
displayName	SREBP1A,1C,2:Importin beta-1 dissociates
edited	[InstanceEdit:2065547] May, B, 2012-01-23
eventOf	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Homo sapiens
followingEvent	[Reaction:R-HSA-2426163] SREBP1A,2 binds the CYP51A1 promoter - Homo sapiens [Reaction:R-HSA-2426160] SREBP1A,1C,2 binds the ACACA promoter - Homo sapiens [Reaction:R-HSA-6800052] SREBP1A,1C binds the SCD gene - Homo sapiens [Reaction:R-HSA-2426164] SREBP1A,2 binds the SC5DL promoter - Homo sapiens [Reaction:R-HSA-2426154] SREBP1A,2 binds the LSS promoter - Homo sapiens [Reaction:R-HSA-2426152] SREBP1A,2 binds the IDI1 promoter - Homo sapiens [Reaction:R-HSA-2426153] SREBP1A,1C binds the ACACB promoter - Homo sapiens [Reaction:R-HSA-2426162] SREBP1A,2 binds the HMGCR promoter - Homo sapiens [Reaction:R-HSA-2426155] SREBP1A,2 binds the DHCR7 promoter - Homo sapiens [Reaction:R-HSA-2426157] SREBP1A,2 binds the MVK promoter - Homo sapiens [Reaction:R-HSA-2426146] SREBP1A,1C,2 binds the FDFT1 promoter - Homo sapiens [Reaction:R-HSA-2426147] SREBP1A,1C,2 binds the FDPS promoter - Homo sapiens [Reaction:R-HSA-2426144] SREBP1A,2 binds the MVD promoter - Homo sapiens [Reaction:R-HSA-2426158] SREBP1A,1C binds the GPAM promoter - Homo sapiens [Reaction:R-HSA-2426150] SREBP1A,1C,2 binds the HMGCS1 promoter - Homo sapiens [Reaction:R-HSA-2426151] SREBP1A,2 binds the SQLE promoter - Homo sapiens [Reaction:R-HSA-2426161] SREBP1A,2 binds the GGPS1 promoter - Homo sapiens [Reaction:R-HSA-2426148] SREBP1A,1C binds the FASN promoter - Homo sapiens [Reaction:R-HSA-2065966] SREBP1A,1C,2 binds the TM7SF2 promoter - Homo sapiens [Reaction:R-HSA-2426149] SREBP1A,1C,2 binds the ELOVL6 promoter - Homo sapiens
input	[Complex:R-HSA-180738] RAN:GTP [nucleoplasm] [Complex:R-HSA-2065543] SREBP1A,1C,2:Importin beta-1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1655706] Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SREBP1A,1C,2:Importin beta-1 dissociates SREBF1A,1C,2:Importin beta-1 dissociates
orthologousEvent	[Reaction:R-CEL-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Caenorhabditis elegans [Reaction:R-DME-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Drosophila melanogaster [Reaction:R-GGA-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Gallus gallus [Reaction:R-XTR-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Xenopus tropicalis [Reaction:R-DRE-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Danio rerio [Reaction:R-BTA-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Bos taurus [Reaction:R-RNO-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Rattus norvegicus [Reaction:R-MMU-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Mus musculus
output	[Complex:R-HSA-180719] Importin-beta:Ran GTP complex [nucleoplasm] [Complex:R-HSA-1655744] SREBP1A,1C,2 dimer [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-1655831] SREBP1A,1C,2 translocates to the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2457630] Liang, Guosheng, 2012-08-25 [InstanceEdit:9963238] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2065539
summation	[Summation:2065536] SREBP1A/1C/2 (SREBF1A/1C/2) dimer dissociates from Importin ...
updateTrackers	[UpdateTracker:9964789] Update Tracker - [Reaction:2065539] SREBP1A,1C,2:Importin beta-1 dissociates - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964789] Update Tracker - [Reaction:2065539] SREBP1A,1C,2:Importin beta-1 dissociates - v94:[removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-2426163] SREBP1A,2 binds the CYP51A1 promoter [Reaction:R-HSA-2426160] SREBP1A,1C,2 binds the ACACA promoter [Reaction:R-HSA-6800052] SREBP1A,1C binds the SCD gene [Reaction:R-HSA-2426164] SREBP1A,2 binds the SC5DL promoter [Reaction:R-HSA-2426154] SREBP1A,2 binds the LSS promoter [Reaction:R-HSA-2426152] SREBP1A,2 binds the IDI1 promoter [Reaction:R-HSA-2426153] SREBP1A,1C binds the ACACB promoter [Reaction:R-HSA-2426162] SREBP1A,2 binds the HMGCR promoter [Reaction:R-HSA-2426155] SREBP1A,2 binds the DHCR7 promoter [Reaction:R-HSA-2426157] SREBP1A,2 binds the MVK promoter [Reaction:R-HSA-2426146] SREBP1A,1C,2 binds the FDFT1 promoter [Reaction:R-HSA-2426147] SREBP1A,1C,2 binds the FDPS promoter [Reaction:R-HSA-2426144] SREBP1A,2 binds the MVD promoter [Reaction:R-HSA-2426158] SREBP1A,1C binds the GPAM promoter [Reaction:R-HSA-2426150] SREBP1A,1C,2 binds the HMGCS1 promoter [Reaction:R-HSA-2426151] SREBP1A,2 binds the SQLE promoter [Reaction:R-HSA-2426161] SREBP1A,2 binds the GGPS1 promoter [Reaction:R-HSA-2426148] SREBP1A,1C binds the FASN promoter [Reaction:R-HSA-2065966] SREBP1A,1C,2 binds the TM7SF2 promoter [Reaction:R-HSA-2426149] SREBP1A,1C,2 binds the ELOVL6 promoter
(hasEvent)	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)

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