Nef mediated activation of the T-cell receptor

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser
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Nef drives the formation of lipid raft complexes.
Literature References
PubMed ID Title Journal Year
11070003 Lentivirus Nef specifically activates Pak2

Molina, RP, Blakemore, JL, Foster, JL, Garcia, JV, Fredericksen, BL, Arora, VK, Chernoff, J

J Virol 2000
11160719 Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

Renkema, GH, Manninen, A, Saksela, K

J Virol 2001
16979207 CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable

Wei, BL, Garcia, JV, Gabuzda, D, Agopian, K

Virology 2007
10607567 Identification of the Nef-associated kinase as p21-activated kinase 2

Renkema, GH, Mann, DA, Manninen, A, Saksela, K, Harris, M

Curr Biol 1999
16188976 Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex

Baugh, LL, Foster, JL, Garcia, JV, Raney, A, Kuo, LS

J Virol 2005
10618429 The Nef protein of HIV-1 associates with rafts and primes T cells for activation

Trono, D, Wang, JK, Verdin, E, Kiyokawa, E

Proc Natl Acad Sci U S A 2000
16282498 Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation

Xiao, GH, Wei, BL, Foster, JL, Garcia, JV, Raney, A, Testa, JR, Arora, VK, Kuo, LS, O'Neill, E

J Virol 2005
Event Information
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
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