Nef mediated activation of the T-cell receptor

Stable Identifier
R-HSA-164943
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
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Nef drives the formation of lipid raft complexes.

Literature References
PubMed ID Title Journal Year
11160719 Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

Renkema, GH, Manninen, A, Saksela, K

J Virol 2001
11070003 Lentivirus Nef specifically activates Pak2

Arora, VK, Molina, RP, Foster, JL, Blakemore, JL, Chernoff, J, Fredericksen, BL, Garcia, JV

J Virol 2000
16979207 CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable

Agopian, K, Wei, BL, Garcia, JV, Gabuzda, D

Virology 2007
10607567 Identification of the Nef-associated kinase as p21-activated kinase 2

Renkema, GH, Manninen, A, Mann, DA, Harris, M, Saksela, K

Curr Biol 1999
16188976 Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex

Raney, A, Kuo, LS, Baugh, LL, Foster, JL, Garcia, JV

J Virol 2005
10618429 The Nef protein of HIV-1 associates with rafts and primes T cells for activation

Wang, JK, Kiyokawa, E, Verdin, E, Trono, D

Proc Natl Acad Sci U S A 2000
16282498 Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation

Wei, BL, Arora, VK, Raney, A, Kuo, LS, Xiao, GH, O'Neill, E, Testa, JR, Foster, JL, Garcia, JV

J Virol 2005
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created