Reactome | Fusion of viral membrane with host cell membrane

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Fusion of viral membrane with host cell membrane Show undefined attributes

authored	[InstanceEdit:176401] Morrow, MP, Bukrinsky, Michael, 2006-03-07
category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:164501] D'Eustachio, P, 2005-05-24 15:07:45
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164524
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Fusion of viral membrane with host cell membrane
edited	[InstanceEdit:174499] Gopinathrao, G, 2006-02-17 18:35:46
eventOf	[Pathway:R-HSA-173107] Binding and entry of HIV virion - Homo sapiens
followingEvent	[Depolymerisation:R-HSA-173642] Disintegration of matrix layer - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6589] fusion of virus membrane with host plasma membrane
input	[Complex:R-HSA-173649] Virion with gp41 forming hairpin structure [extracellular region]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:175678] Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements [LiteratureReference:175735] Novel therapies based on mechanisms of HIV-1 cell entry [LiteratureReference:177628] Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection [LiteratureReference:175804] Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1 [Book:177559] 9780879695712 Viral Entry and Receptors Retroviruses Hunter, E [LiteratureReference:177601] Structural features of membrane fusion between influenza virus and liposome as revealed by quick-freezing electron microscopy [LiteratureReference:177591] Quantitative measurement of fusion between human immunodeficiency virus and cultured cells using membrane fluorescence dequenching [LiteratureReference:165614] Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced [LiteratureReference:181878] Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fusion of viral membrane with host cell membrane
output	[Complex:R-HSA-171297] CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] [Complex:R-HSA-173664] Viral core surrounded by Matrix layer [cytosol]
precedingEvent	[Reaction:R-HSA-164508] N and C terminal heptad repeat helices of gp41 form six-helix bundle - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181880] Reeves, J, 2006-06-12 15:22:40
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164524
summation	[Summation:177577] With the transition of gp41 into the six-helix bundle, fusio...

Referrals

(precedingEvent)	[Depolymerisation:R-HSA-173642] Disintegration of matrix layer
(hasEvent)	[Pathway:R-HSA-173107] Binding and entry of HIV virion