Transcriptional activation of AGPAT1 by ChREBP:MLX

Stable Identifier
R-HSA-163748
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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Transcriptional activation of AGPAT1 by ChREBP:MLX
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The AGPAT1 (1-acyl-sn-glycerol-3-phosphate acyltransferase alpha) gene, activated by binding of MLXIPL:MLX (ChREBP:MLX) to its promoter region, is transcribed and the resulting mRNA is translated to yield ACACB protein (Ma et al. 2005, 2006, 2007).
Literature References
PubMed ID Title Journal Year
17148476 A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

Ma, L, Sham, YY, Walters, KJ, Towle, HC

Nucleic Acids Res. 2007
16885160 ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver

Ma, L, Robinson, LN, Towle, HC

J. Biol. Chem. 2006
15664996 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Ma, L, Tsatsos, NG, Towle, HC

J Biol Chem 2005
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Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of transcription by RNA polymerase II (0045944)
This event is regulated
Positively by
Regulator
MLXIPL:MLX: AGPAT1 gene [nucleoplasm] (Homo sapiens)
Reviewed
Hill, DP  (2024-02-12)
Created
Gopinathrao, G  (2005-05-06)
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