Formation of ChREBP:MLX heterodimer

Stable Identifier
R-HSA-163666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of ChREBP:MLX heterodimer
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Dephosphorylation of ChREBP protein enables it to enter the nucleus, where it binds MLX protein to form a heterodimer that acts as a transcription factor to enable the expression of genes like PKLR, ACLY, FASN, ACACA, ACACB, and AGPAT associated with metabolism in the well-fed state (Ma et al. 2005).
Literature References
PubMed ID Title Journal Year
15664996 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Ma, L, Tsatsos, NG, Towle, HC

J Biol Chem 2005
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Catalyst Activity

DNA-binding transcription factor activity of MLX [nucleoplasm]

Physical Entity
MLX [nucleoplasm] (Homo sapiens)
Activity
DNA-binding transcription factor activity (GO:0003700)
Inferred From
Formation of mChREBP:mMlx complex (Mus musculus)
Reviewed
Hill, DP  (2024-02-12)
Created
Gopinathrao, G  (2005-05-05)
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