Reactome | Disassociation of Telomerase RNP and the Chromosome End

Schema > Reaction > Entries

Disassociation of Telomerase RNP and the Chromosome End Show undefined attributes

authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity	[CatalystActivity:9671062] 5'-3' DNA/RNA helicase activity of PIF1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:163119] Gillespie, ME, 2005-04-18 03:27:52
dbId	163120
displayName	Disassociation of Telomerase RNP and the Chromosome End
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf	[Pathway:R-HSA-171319] Telomere Extension By Telomerase - Homo sapiens
figure	[Figure:163118] /figures/telomerase_release.jpg
followingEvent	[Reaction:R-HSA-9668597] DNA polymerase:primase binds G-strand of the telomere - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18229] telomere maintenance via telomerase
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-HSA-164619] Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:184137] The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity [LiteratureReference:9671058] Human PIF helicase is cell cycle regulated and associates with telomerase [LiteratureReference:9671069] Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity [LiteratureReference:9671060] Pif1 family helicases suppress genome instability at G-quadruplex motifs
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Disassociation of Telomerase RNP and the Chromosome End
orthologousEvent	[Reaction:R-GGA-418082] Dissociation of telomerase RNP from the extended chromosomal end - Gallus gallus [Reaction:R-SSC-163120] Disassociation of Telomerase RNP and the Chromosome End - Sus scrofa [Reaction:R-BTA-163120] Disassociation of Telomerase RNP and the Chromosome End - Bos taurus [Reaction:R-RNO-163120] Disassociation of Telomerase RNP and the Chromosome End - Rattus norvegicus [Reaction:R-MMU-163120] Disassociation of Telomerase RNP and the Chromosome End - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5686112] RTEL1 [nucleoplasm] [Complex:R-HSA-163101] Telomerase RNP [nucleoplasm] [Complex:R-HSA-9671097] Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-164617] Elongation of Extended Telomeric Chromosome End - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-163120
summation	[Summation:174876] In vitro, telomerase can disassociate from the primer follow...
updateTrackers	[UpdateTracker:9777086] Update Tracker - [Reaction:163120] Disassociation of Telomerase RNP and the Chromosome End - v72:[addCatalystActivity, addInput, add_removeLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777086] Update Tracker - [Reaction:163120] Disassociation of Telomerase RNP and the Chromosome End - v72:[addCatalystActivity, addInput, add_removeLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-171319] Telomere Extension By Telomerase
(precedingEvent)	[Reaction:R-HSA-9668597] DNA polymerase:primase binds G-strand of the telomere [NegativePrecedingEvent:9766485] Futile Cycle: Disassociation of Telomerase RNP and the Chromosome End

Cite Us!