Reactome | Disassociation of Telomerase RNP and the Chromosome End

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Disassociation of Telomerase RNP and the Chromosome End Show undefined attributes

catalystActivity	[CatalystActivity:9995539] 5'-3' DNA/RNA helicase activity of PIF1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9995541
displayName	Disassociation of Telomerase RNP and the Chromosome End
eventOf	[Pathway:R-MMU-171319] Telomere Extension By Telomerase - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9668597] DNA polymerase:primase binds G-strand of the telomere - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:18229] telomere maintenance via telomerase
inferredFrom	[Reaction:R-HSA-163120] Disassociation of Telomerase RNP and the Chromosome End - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-MMU-164619] Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Disassociation of Telomerase RNP and the Chromosome End
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5686112] RTEL1 [nucleoplasm] [Complex:R-MMU-163101] Telomerase RNP [nucleoplasm] [Complex:R-MMU-9671097] Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-MMU-164617] Elongation of Extended Telomeric Chromosome End - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-163120
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-171319] Telomere Extension By Telomerase
(precedingEvent)	[Reaction:R-MMU-9668597] DNA polymerase:primase binds G-strand of the telomere
(inferredTo)	[Reaction:R-HSA-163120] Disassociation of Telomerase RNP and the Chromosome End

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