Reactome | uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

Schema > Reaction > Entries

uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide Show undefined attributes

authored	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
catalystActivity	[CatalystActivity:162847] GPI-anchor transamidase activity of GPI transamidase [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId	162836
displayName	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-162791] Attachment of GPI anchor to uPAR - Homo sapiens
followingEvent	[Reaction:R-HSA-162729] uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid - Homo sapiens
input	[SimpleEntity:R-ALL-8855660] (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-162866] PLAUR(23-335) [endoplasmic reticulum membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:162864] Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins [LiteratureReference:162723] PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 [LiteratureReference:162817] The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
orthologousEvent	[Reaction:R-SSC-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - Sus scrofa [Reaction:R-BTA-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - Bos taurus [Reaction:R-CFA-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - Canis familiaris [Reaction:R-RNO-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - Rattus norvegicus [Reaction:R-MMU-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-162687] GPI-PLAUR [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-162707] PLAUR(306-335) [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-163069] mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-162836
summation	[Summation:162780] In the endoplasmic reticulum, the precursor form of urokinas...
updateTrackers	[UpdateTracker:9783437] Update Tracker - [Reaction:162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - v56:[add_removeInput] [UpdateTracker:9783102] Update Tracker - [Reaction:162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - v57:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9783437] Update Tracker - [Reaction:162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - v56:[add_removeInput] [UpdateTracker:9783102] Update Tracker - [Reaction:162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - v57:[add_removeInput]
(precedingEvent)	[Reaction:R-HSA-162729] uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
(hasEvent)	[Pathway:R-HSA-162791] Attachment of GPI anchor to uPAR

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