Reactome | uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

Schema > Reaction > Entries

uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide Show undefined attributes

catalystActivity	[CatalystActivity:10236902] GPI-anchor transamidase activity of GPI transamidase [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10236904
displayName	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
eventOf	[Pathway:R-CFA-162791] Attachment of GPI anchor to uPAR - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-162729] uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid - Canis familiaris
inferredFrom	[Reaction:R-HSA-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide - Homo sapiens
input	[SimpleEntity:R-ALL-8855660] (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-CFA-162866] PLAUR(23-335) [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
output	[EntityWithAccessionedSequence:R-CFA-162687] GPI-PLAUR [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-CFA-162707] PLAUR(306-335) [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-162836
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-162791] Attachment of GPI anchor to uPAR
(precedingEvent)	[Reaction:R-CFA-162729] uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
(inferredTo)	[Reaction:R-HSA-162836] uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

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