Reactome | In the endoplasmic reticulum, the precursor form of urokinas...

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created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId	162780
displayName	In the endoplasmic reticulum, the precursor form of urokinas...
literatureReference	[LiteratureReference:162864] Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins [LiteratureReference:162723] PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 [LiteratureReference:162817] The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase
schemaClass	Summation
text	In the endoplasmic reticulum, the precursor form of urokinase plasminogen activator receptor is transamidated at residue 305, replacing the 30 carboxyterminal residues of the protein with an acylated glucosylphosphatidylinositol (acyl-GPI) moiety. The released carboxyterminal propeptide has no known function. The reaction is catalyzed by GPI transamidase, a complex of at least five proteins associated with the lumenal surface of the endoplasmic reticulum membrane (Yu et al. 1997; Ohishi et al. 2001; Hong et al. 2003).

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