Reactome | uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

Stable Identifier

R-HSA-162836

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

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In the endoplasmic reticulum, the precursor form of urokinase plasminogen activator receptor is transamidated at residue 305, replacing the 30 carboxyterminal residues of the protein with an acylated glucosylphosphatidylinositol (acyl-GPI) moiety. The released carboxyterminal propeptide has no known function. The reaction is catalyzed by GPI transamidase, a complex of at least five proteins associated with the lumenal surface of the endoplasmic reticulum membrane (Yu et al. 1997; Ohishi et al. 2001; Hong et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
9356492	The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase Yu, J, Nagarajan, S, Knez, JJ, Udenfriend, S, Chen, R, Medof, ME	Proc Natl Acad Sci U S A	1997
12802054	Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins Hong, Y, Ohishi, K, Kang, JY, Tanaka, S, Inoue, N, Nishimura, J, Maeda, Y, Kinoshita, T	Mol Biol Cell	2003
11483512	PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 Ohishi, K, Inoue, N, Kinoshita, T	EMBO J	2001