uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

Stable Identifier
Reaction [transition]
Homo sapiens
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In the endoplasmic reticulum, the precursor form of urokinase plasminogen activator receptor is transamidated at residue 305, replacing the 30 carboxyterminal residues of the protein with an acylated glucosylphosphatidylinositol (acyl-GPI) moiety. The released carboxyterminal propeptide has no known function. The reaction is catalyzed by GPI transamidase, a complex of at least five proteins associated with the lumenal surface of the endoplasmic reticulum membrane (Yu et al. 1997; Ohishi et al. 2001; Hong et al. 2003).
Literature References
PubMed ID Title Journal Year
9356492 The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

Yu, J, Nagarajan, S, Medof, ME, Udenfriend, S, Knez, JJ, Chen, R

Proc Natl Acad Sci U S A 1997
12802054 Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins

Kinoshita, T, Nishimura, J, Kang, JY, Tanaka, S, Inoue, N, Ohishi, K, Hong, Y, Maeda, Y

Mol Biol Cell 2003
11483512 PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

Kinoshita, T, Inoue, N, Ohishi, K

EMBO J 2001
Catalyst Activity

GPI-anchor transamidase activity of GPI transamidase [endoplasmic reticulum membrane]

Orthologous Events
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