Reactome | ELANE [extracellular region]

candidateOf	[CandidateSet:R-HSA-8852723] Activated thrombin, (ELANE) [extracellular region] - Homo sapiens [CandidateSet:R-HSA-1604762] MMP7 initial activators [extracellular region] - Homo sapiens
catalystActivities	[CatalystActivity:2482187] serine-type endopeptidase activity of ELANE [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-9911480] ELANE:NOTCH2NLA [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9911230] ELANE binds NOTCH2NLA - Homo sapiens
created	[InstanceEdit:1602467] Jupe, S, 2011-09-14
dbId	1602474
displayName	ELANE [extracellular region]
endCoordinate	267
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-1602474] Elane [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-RNO-1602474] Elane [extracellular region] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-1602474] ELANE [extracellular region] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-1602474] ELANE [extracellular region] - Bos taurus [EntityWithAccessionedSequence:R-SSC-1602474] ELANE [extracellular region] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-1602474] prtn3 [extracellular region] - Xenopus tropicalis
maxDepth	1
memberOf	[DefinedSet:R-HSA-2533968] MMP1, MMP9, MMP12, ELANE [extracellular region] - Homo sapiens [DefinedSet:R-HSA-2127623] proMMP8 initial activators [extracellular region] - Homo sapiens [DefinedSet:R-HSA-2514800] Elastin-degrading extracellular proteinases [extracellular region] - Homo sapiens [DefinedSet:R-HSA-1602468] proMMP1 initial activators [extracellular region] - Homo sapiens [DefinedSet:R-HSA-6806312] Specific granule lumen proteins [extracellular region] - Homo sapiens [DefinedSet:R-HSA-6806184] Azurophil granule lumen proteins [extracellular region] - Homo sapiens
modified	[InstanceEdit:2485082] Jupe, S, 2012-09-28
name	ELANE Neutrophil elastase ELA2 ELNE_HUMAN
producedByEvent	[BlackBoxEvent:R-HSA-9911236] ELANE cleaves NOTCH2NLA - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P08246] UniProt:P08246 ELANE
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1602474
startCoordinate	30
updateTrackers	[UpdateTracker:9874554] Update Tracker - [EntityWithAccessionedSequence:1602474] ELANE [extracellular region] - v43:[addName]

(updatedInstance)	[UpdateTracker:9874554] Update Tracker - [EntityWithAccessionedSequence:1602474] ELANE [extracellular region] - v43:[addName]
(hasMember)	[DefinedSet:R-HSA-2514800] Elastin-degrading extracellular proteinases [extracellular region] [DefinedSet:R-HSA-2533968] MMP1, MMP9, MMP12, ELANE [extracellular region] [DefinedSet:R-HSA-2127623] proMMP8 initial activators [extracellular region] [DefinedSet:R-HSA-1602468] proMMP1 initial activators [extracellular region] [DefinedSet:R-HSA-6806312] Specific granule lumen proteins [extracellular region] [DefinedSet:R-HSA-6806184] Azurophil granule lumen proteins [extracellular region] [DefinedSet:R-HSA-6813639] ELANE, CTSG, PRTN3 [extracellular region]
(physicalEntity)	[CatalystActivity:2482187] serine-type endopeptidase activity of ELANE [extracellular region]
(hasCandidate)	[CandidateSet:R-HSA-1604762] MMP7 initial activators [extracellular region] [CandidateSet:R-HSA-8852723] Activated thrombin, (ELANE) [extracellular region]
(input)	[Reaction:R-HSA-9911230] ELANE binds NOTCH2NLA
(output)	[BlackBoxEvent:R-HSA-9911236] ELANE cleaves NOTCH2NLA
(hasComponent)	[Complex:R-HSA-9911480] ELANE:NOTCH2NLA [extracellular region]
(activeUnit)	[CatalystActivity:9911491] serine-type endopeptidase activity of ELANE:NOTCH2NLA [extracellular region]

ELANE [extracellular region] Show undefined attributes

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