Reactome | ELANE cleaves NOTCH2NLA

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ELANE cleaves NOTCH2NLA Show undefined attributes

authored	[InstanceEdit:9911795] Orlic-Milacic, Marija, 2024-06-05
catalystActivity	[CatalystActivity:9911491] serine-type endopeptidase activity of ELANE:NOTCH2NLA [extracellular region]
category	uncertain
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9911235] Orlic-Milacic, Marija, 2024-05-27
dbId	9911236
displayName	ELANE cleaves NOTCH2NLA
edited	[InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
eventOf	[Pathway:R-HSA-9911233] Expression of NOTCH2NL genes - Homo sapiens
input	[Complex:R-HSA-9911480] ELANE:NOTCH2NLA [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9911328] A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia
maxDepth	1
modified	[InstanceEdit:9925767] Orlic-Milacic, Marija, 2024-10-24
name	ELANE cleaves NOTCH2NLA
output	[EntityWithAccessionedSequence:R-HSA-1602474] ELANE [extracellular region] [EntityWithAccessionedSequence:R-HSA-9911493] NOTCH2NLA(1-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-9911490] NOTCH2NLA(?-236) [extracellular region]
precedingEvent	[Reaction:R-HSA-9911230] ELANE binds NOTCH2NLA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9925739] Heide, Michael, 2024-10-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9911236
summation	[Summation:9911492] ELANE (also known as ELA2 or NE), a human neutrophil elas...

Referrals

(hasEvent)	[Pathway:R-HSA-9911233] Expression of NOTCH2NL genes
(precedingEvent)	[NegativePrecedingEvent:9911794] Futile Cycle: ELANE cleaves NOTCH2NLA

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