Reactome | ELANE binds NOTCH2NLA

Schema > Reaction > Entries

authored	[InstanceEdit:9911795] Orlic-Milacic, Marija, 2024-06-05
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9911235] Orlic-Milacic, Marija, 2024-05-27
dbId	9911230
displayName	ELANE binds NOTCH2NLA
edited	[InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
eventOf	[Pathway:R-HSA-9911233] Expression of NOTCH2NL genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9911236] ELANE cleaves NOTCH2NLA - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1602474] ELANE [extracellular region] [EntityWithAccessionedSequence:R-HSA-9908935] NOTCH2NLA [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9911328] A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia
maxDepth	1
modified	[InstanceEdit:9925767] Orlic-Milacic, Marija, 2024-10-24
name	ELANE binds NOTCH2NLA
negativePrecedingEvent	[NegativePrecedingEvent:9911794] Futile Cycle: ELANE cleaves NOTCH2NLA
output	[Complex:R-HSA-9911480] ELANE:NOTCH2NLA [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-9925730] Translation of NOTCH2NLA mRNA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9925739] Heide, Michael, 2024-10-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9911230
summation	[Summation:9911481] ELANE (also known as ELA2 or NE), a human neutrophil elas...

(hasEvent)	[Pathway:R-HSA-9911233] Expression of NOTCH2NL genes
(precedingEvent)	[BlackBoxEvent:R-HSA-9911236] ELANE cleaves NOTCH2NLA

Cite Us!