Reactome | Phosphorylation of SMAD2,3 by Activin:Activin Receptor

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Phosphorylation of SMAD2,3 by Activin:Activin Receptor Show undefined attributes

authored	[InstanceEdit:1549502] May, B, 2011-08-28
catalystActivity	[CatalystActivity:1549514] protein serine/threonine kinase activity of Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1549515] May, B, 2011-08-29
dbId	1549526
displayName	Phosphorylation of SMAD2,3 by Activin:Activin Receptor
edited	[InstanceEdit:1549502] May, B, 2011-08-28
eventOf	[Pathway:R-HSA-1502540] Signaling by Activin - Homo sapiens
followingEvent	[Reaction:R-HSA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-171172] SMAD2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1549510] Receptor internalization-independent activation of Smad2 in activin signaling [LiteratureReference:1549528] MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4 [LiteratureReference:1549512] Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells [LiteratureReference:1549527] Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression [LiteratureReference:2470489] Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Phosphorylation of SMAD2,3 by Activin:Activin Receptor
orthologousEvent	[Reaction:R-DME-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Drosophila melanogaster [Reaction:R-GGA-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Gallus gallus [Reaction:R-XTR-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Xenopus tropicalis [Reaction:R-DRE-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Danio rerio [Reaction:R-SSC-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Sus scrofa [Reaction:R-BTA-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Bos taurus [Reaction:R-CFA-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Canis familiaris [Reaction:R-RNO-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Rattus norvegicus [Reaction:R-MMU-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-171182] p-2S-SMAD2,3 [cytosol]
precedingEvent	[Reaction:R-HSA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin - Homo sapiens [Reaction:R-HSA-2470508] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1549526
summation	[Summation:2470477] Activin receptors containing the type II receptors ACVR2A/B ...

Referrals

(hasEvent)	[Pathway:R-HSA-1502540] Signaling by Activin
(precedingEvent)	[Reaction:R-HSA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4