Activin receptors containing the type II receptors ACVR2A/B ...

created [InstanceEdit:2470496] May, B, 2012-09-18
dbId 2470477
displayName Activin receptors containing the type II receptors ACVR2A/B ...
schemaClass Summation
text Activin receptors containing the type II receptors ACVR2A/B (ActRIIA, ActRIIB) and the type I receptors ACVR1B/C (ALK4, ALK7) signal through SMAD2 and SMAD3. The phosphorylated type I receptor (ACVR1B/C) phosphorylates SMAD2 or SMAD3. Homodimers or heterodimers of SMAD2 and SMAD3 bind the co-Smad SMAD4 and the ternary complex (SMAD2/3:SMAD2/3:SMAD4) enters the nucleus and activates expression of target genes.
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