Reactome | Signaling by Activin

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Signaling by Activin Show undefined attributes

authored	[InstanceEdit:1502538] May, B, 2011-08-23
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1502542] May, B, 2011-08-23
crossReference	[DatabaseIdentifier:12819621] BioModels Database:BIOMD0000000173
dbId	1502540
displayName	Signaling by Activin
doi	10.3180/REACT_150238.1
edited	[InstanceEdit:1502538] May, B, 2011-08-23
eventOf	[Pathway:R-HSA-9006936] Signaling by TGFB family members - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1181153] Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B - Homo sapiens [Reaction:R-HSA-2470483] Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C - Homo sapiens [Reaction:R-HSA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin - Homo sapiens [Reaction:R-HSA-2470508] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin - Homo sapiens [Reaction:R-HSA-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Homo sapiens [Reaction:R-HSA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Homo sapiens [BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens [Reaction:R-HSA-1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element - Homo sapiens [Pathway:R-HSA-2473224] Antagonism of Activin by Follistatin - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:1181075] Activation of signalling by the activin receptor complex [LiteratureReference:208144] Formation and activation by phosphorylation of activin receptor complexes [LiteratureReference:2470506] Structural studies of the TGF-?s and their receptors - insights into evolution of the TGF-? superfamily [LiteratureReference:2584278] Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis
maxDepth	3
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by Activin
orthologousEvent	[Pathway:R-CEL-1502540] Signaling by Activin - Caenorhabditis elegans [Pathway:R-DME-1502540] Signaling by Activin - Drosophila melanogaster [Pathway:R-GGA-1502540] Signaling by Activin - Gallus gallus [Pathway:R-XTR-1502540] Signaling by Activin - Xenopus tropicalis [Pathway:R-DRE-1502540] Signaling by Activin - Danio rerio [Pathway:R-SSC-1502540] Signaling by Activin - Sus scrofa [Pathway:R-BTA-1502540] Signaling by Activin - Bos taurus [Pathway:R-CFA-1502540] Signaling by Activin - Canis familiaris [Pathway:R-RNO-1502540] Signaling by Activin - Rattus norvegicus [Pathway:R-MMU-1502540] Signaling by Activin - Mus musculus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1502540
summation	[Summation:1502541] Activin was initially discovered as an activator of follicle...
updateTrackers	[UpdateTracker:9780292] Update Tracker - [Pathway:1502540] Signaling by Activin - v63:[updateContainedPathway] [UpdateTracker:9842332] Update Tracker - [Pathway:1502540] Signaling by Activin - v86:[updateContainedRLE] [UpdateTracker:9775906] Update Tracker - [Pathway:1502540] Signaling by Activin - v78:[updateContainedRLE] [UpdateTracker:9787878] Update Tracker - [Pathway:1502540] Signaling by Activin - v44:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9780292] Update Tracker - [Pathway:1502540] Signaling by Activin - v63:[updateContainedPathway] [UpdateTracker:9842332] Update Tracker - [Pathway:1502540] Signaling by Activin - v86:[updateContainedRLE] [UpdateTracker:9775906] Update Tracker - [Pathway:1502540] Signaling by Activin - v78:[updateContainedRLE] [UpdateTracker:9787878] Update Tracker - [Pathway:1502540] Signaling by Activin - v44:[updateContainedRLE]
(hasEncapsulatedEvent)	[Pathway:R-HSA-9839373] Signaling by TGFBR3
(hasEvent)	[Pathway:R-HSA-9006936] Signaling by TGFB family members

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