Phosphorylation of SMAD2,3 by Activin:Activin Receptor

Stable Identifier
Reaction [transition]
Homo sapiens
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Activin receptors containing the type II receptors ACVR2A/B (ActRIIA, ActRIIB) and the type I receptors ACVR1B/C (ALK4, ALK7) signal through SMAD2 and SMAD3. The phosphorylated type I receptor (ACVR1B/C) phosphorylates SMAD2 or SMAD3. Homodimers or heterodimers of SMAD2 and SMAD3 bind the co-Smad SMAD4 and the ternary complex (SMAD2/3:SMAD2/3:SMAD4) enters the nucleus and activates expression of target genes.
Literature References
PubMed ID Title Journal Year
16140969 Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells

Woodruff, TK, Lee, EJ, Jeruss, JS, Burdette, JE, Kurley, SJ

Cancer Res 2005
17906079 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4

Wang, Q, Xue, H, Huang, Z, Ju, XL, Jin, C, Han, JD, Chen, YG

Blood 2008
18951876 Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells

Yamada, Y, Tsuda, K, Watanabe, R, Shen, ZP

Biochem. Biophys. Res. Commun. 2008
15087470 Receptor internalization-independent activation of Smad2 in activin signaling

Klibanski, A, Zhou, Y, Funderburk, SF, Ficociello, LF, Zhang, X, Scolavino, S

Mol Endocrinol 2004
18166170 Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression

Childs, AJ, McNeilly, AS, Anderson, RA, Fulton, N, Coutts, SM, Bayne, RA, Collins, C

Dev Biol 2008
Catalyst Activity

protein serine/threonine kinase activity of Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane]

Orthologous Events
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