Phosphorylation of SMAD2/3 by Activin:Activin Receptor

Stable Identifier
R-HSA-1549526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activin receptors containing the type II receptors ACVR2A/B (ActRIIA, ActRIIB) and the type I receptors ACVR1B/C (ALK4, ALK7) signal through SMAD2 and SMAD3. The phosphorylated type I receptor (ACVR1B/C) phosphorylates SMAD2 or SMAD3. Homodimers or heterodimers of SMAD2 and SMAD3 bind the co-Smad SMAD4 and the ternary complex (SMAD2/3:SMAD2/3:SMAD4) enters the nucleus and activates expression of target genes.

Literature References
PubMed ID Title Journal Year
17906079 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4

Wang, Q, Huang, Z, Xue, H, Jin, C, Ju, XL, Han, JD, Chen, YG

Blood 2008
16140969 Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells

Burdette, JE, Jeruss, JS, Kurley, SJ, Lee, EJ, Woodruff, TK

Cancer Res 2005
18951876 Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells

Watanabe, R, Shen, ZP, Tsuda, K, Yamada, Y

Biochem. Biophys. Res. Commun. 2008
15087470 Receptor internalization-independent activation of Smad2 in activin signaling

Zhou, Y, Scolavino, S, Funderburk, SF, Ficociello, LF, Zhang, X, Klibanski, A

Mol Endocrinol 2004
18166170 Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression

Coutts, SM, Childs, AJ, Fulton, N, Collins, C, Bayne, RA, McNeilly, AS, Anderson, RA

Dev Biol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane]
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Activity
Orthologous Events
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Reviewed
Created