Reactome | PIK3CA E545K [cytosol]

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PIK3CA E545K [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference	[DatabaseIdentifier:12021360] Mondo:0004631 [DatabaseIdentifier:2328087] COSMIC:COSV55873239 [DatabaseIdentifier:2328088] COSMIC:COSM29328
dbId	1500706
disease	[Disease:1248674] large intestine cancer [Disease:1500699] lung cancer [Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1500687] stomach cancer [Disease:2327996] gallbladder carcinoma [Disease:1614289] melanoma [Disease:1500575] ovarian cancer [Disease:2317358] endometrial cancer [Disease:1493885] bladder carcinoma [Disease:2327997] pharynx cancer [Disease:2327994] penis carcinoma [Disease:2327998] esophageal carcinoma [Disease:2327989] bile duct carcinoma [Disease:1614672] cervical cancer [Disease:1655470] thyroid cancer [Disease:1247632] glioblastoma [Disease:2318519] medulloblastoma [Disease:1996312] brain glioma [Disease:2328000] gum cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:2328001] skin squamous cell carcinoma [Disease:1655484] kidney cancer [Disease:2328197] renal pelvis carcinoma [Disease:2328200] tongue cancer [Disease:2328202] eccrine sweat gland cancer [Disease:2328198] pancreatic cancer [Disease:2328196] pituitary adenoma [Disease:2328199] basal cell carcinoma [Disease:2328201] myeloma [Disease:2396014] seborrheic keratosis
displayName	PIK3CA E545K [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:1500692] L-glutamic acid 545 replaced with L-lysine
inDisease	true
literatureReference	[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
maxDepth	1
memberOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA E545K PIK3CA Glu545Lys
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1500706
startCoordinate	1
summation	[Summation:2399586] Substitution of glutamic acid residue at position 545 of PIK...
updateTrackers	[UpdateTracker:9888245] Update Tracker - [EntityWithAccessionedSequence:1500706] PIK3CA E545K [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9888245] Update Tracker - [EntityWithAccessionedSequence:1500706] PIK3CA E545K [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]

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