Reactome | Substitution of glutamic acid residue at position 545 of PIK...

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created	[InstanceEdit:2399582] Orlic-Milacic, M, 2012-07-11
dbId	2399586
displayName	Substitution of glutamic acid residue at position 545 of PIK...
literatureReference	[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
schemaClass	Summation
text	Substitution of glutamic acid residue at position 545 of PIK3CA with lysine disrupts inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1. The PI3K complex containing PIK3CA E545K mutant is constitutively active under serum starved conditions (Miled et al. 2007, Huang et al. 2007, Zhao et al. 2005).

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