Peroxynitrite can oxidise BH4 to the BH3 radical

Stable Identifier
R-HSA-1497866
Type
Reaction [transition]
Species
Homo sapiens
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Peroxynitrite can oxidise BH4 to the BH3 radical, further reducing BH4 availability to couple eNOS activity and compounding the production of superoxide through uncoupled eNOS activity (Kuzkaya et al. 2003).

Literature References
PubMed ID Title Journal Year
12692136 Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase

Kuzkaya, N, Weissmann, N, Harrison, DG, Dikalov, S

J Biol Chem 2003
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