Peroxynitrite can oxidise BH4 to the BH3 radical

Stable Identifier
R-HSA-1497866
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Peroxynitrite can oxidise BH4 to the BH3 radical
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxynitrite can oxidise BH4 to the BH3 radical, further reducing BH4 availability to couple eNOS activity and compounding the production of superoxide through uncoupled eNOS activity (Kuzkaya et al. 2003).

Literature References
PubMed ID Title Journal Year
12692136 Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase

Kuzkaya, N, Weissmann, N, Harrison, DG, Dikalov, S

J Biol Chem 2003
Participants
Input
Output
Participant Of
hasEvent
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
Cite Us!