Reactome | Ascorbate can reduce the BH3 radical back to BH4

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Ascorbate can reduce the BH3 radical back to BH4 Show undefined attributes

authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
dbId	1497855
displayName	Ascorbate can reduce the BH3 radical back to BH4
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
eventOf	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle - Homo sapiens [Reaction:R-HSA-1497866] Peroxynitrite can oxidise BH4 to the BH3 radical - Homo sapiens
input	[SimpleEntity:R-ALL-198816] AscH- [cytosol] [SimpleEntity:R-ALL-1497797] BH3. [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1497790] Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells [LiteratureReference:1497808] Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase [LiteratureReference:1497835] Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ascorbate can reduce the BH3 radical back to BH4
output	[SimpleEntity:R-ALL-1497805] Asc.- [cytosol] [SimpleEntity:R-ALL-29870] BH4 [cytosol]
precedingEvent	[Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1497855
summation	[Summation:1497781] Ascorbate (AscH-) can reduce the BH3 radical back to BH4, th...
updateTrackers	[UpdateTracker:9777732] Update Tracker - [Reaction:1497855] Ascorbate can reduce the BH3 radical back to BH4 - v69:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777732] Update Tracker - [Reaction:1497855] Ascorbate can reduce the BH3 radical back to BH4 - v69:[modifyText]
(precedingEvent)	[Reaction:R-HSA-1497866] Peroxynitrite can oxidise BH4 to the BH3 radical [Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle
(hasEvent)	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

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