PE is converted to PS by PTDSS2

Stable Identifier
R-HSA-1483089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PE is converted to PS by PTDSS2
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At the endoplasmic reticulum (ER) membrane, phosphatidylserine synthase 2 (PTDSS2) converts phosphatidylethanolamine (PE) into phosphatidylserine (PS) by facilitating the exchange of L-Serine (L-Ser) with the ethanolamine (ETA) head group (Saito et al. 1998, Tomohiro et al. 2009).

Literature References
PubMed ID Title Journal Year
9642289 Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells

Saito, K, Kuge, O, Nishijima, M

J Biol Chem 1998
19014349 Purification and characterization of human phosphatidylserine synthases 1 and 2

Kawabe, Y, Kitada, S, Tomohiro, S, Kuge, O, Kawaguti, A

Biochem J 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

transferase activity of PTDSS2 [endoplasmic reticulum membrane]

Physical Entity
PTDSS2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
transferase activity (GO:0016740)
Orthologous Events
PE is converted to PS by PTDSS2 (Bos taurus)
PE is converted to PS by PTDSS2 (Canis familiaris)
PE is converted to PS by PTDSS2 (Danio rerio)
PE is converted to PS by PTDSS2 (Dictyostelium discoideum)
PE is converted to PS by PTDSS2 (Gallus gallus)
PE is converted to PS by PTDSS2 (Mus musculus)
PE is converted to PS by PTDSS2 (Plasmodium falciparum)
PE is converted to PS by PTDSS2 (Rattus norvegicus)
PE is converted to PS by PTDSS2 (Sus scrofa)
PE is converted to PS by PTDSS2 (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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