At the endoplasmic reticulum (ER) membrane, phosphatidyletha...

created [InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId 1482795
displayName At the endoplasmic reticulum (ER) membrane, phosphatidyletha...
modified [InstanceEdit:2230933] D'Eustachio, P, 2012-05-05
schemaClass Summation
text At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off by cytosolic phospholipase A2 alpha/delta/epsilon/zeta (PLA2G4A/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylethanolamine (LPE). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Cite Us!