MLCL is acylated to CL by HADH (IM)

Stable Identifier
R-HSA-1482775
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial matrix
ReviewStatus
5/5
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MLCL is acylated to CL by HADH (IM)
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At the inner mitochondrial membrane (IM), the trifunctional enzyme HADH (3-hydroxyacyl-CoA dehydrogenase), an octamer of four alpha (HADHA) and four beta (HADHB) subunits, acylates monolysocardiolipin (MLCL) to cardiolipin (CL) (Taylor & Hatch 2009).
Literature References
PubMed ID Title Journal Year
19737925 Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)

Taylor, WA, Hatch, GM

J Biol Chem 2009
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Catalyst Activity

O-acyltransferase activity of HADH octamer [mitochondrial inner membrane]

Physical Entity
HADH octamer [mitochondrial inner membrane] (Homo sapiens)
Activity
O-acyltransferase activity (GO:0008374)
Orthologous Events
MLCL is acylated to CL by HADH (IM) (Bos taurus)
MLCL is acylated to CL by HADH (IM) (Caenorhabditis elegans)
MLCL is acylated to CL by HADH (IM) (Canis familiaris)
MLCL is acylated to CL by HADH (IM) (Danio rerio)
MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)
MLCL is acylated to CL by HADH (IM) (Gallus gallus)
MLCL is acylated to CL by HADH (IM) (Mus musculus)
MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)
MLCL is acylated to CL by HADH (IM) (Sus scrofa)
MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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