6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (Takikawa et al. 1986) catalyses the second step in BH4 biosynthesis, the dephosphorylation of DHNTP to 6-pyruvoyl-tetrahydropterin (PTHP). PTPS is believed to function as a homohexamer (Nar et al. 1994, Bürgisser et al. 1994) and has a requirement for Zn2+ (one Zn2+ ion bound per subunit) and Mg2+ ions for activity (Bürgisser et al. 1995). The phosphorylation of Ser-19 is an essential modification for enzyme activity (Scherer-Oppliger et al. 1999).
Hess, D, Nar, H, Thöny, B, Bürgisser, DM, Heizmann, CW, Redweik, U, Huber, R
Nar, H, Thöny, B, Heizmann, CW, Bürgisser, D, Huber, R
Blau, N, Thöny, B, Bürgisser, DM, Hunziker, P, Heizmann, CW, Redweik, U
Scherer-Oppliger, T, Blau, N, Thöny, B, Leimbacher, W
Ghisla, S, Leimbacher, W, Redweik, U, Takikawa, S, Curtius, HC
6-pyruvoyltetrahydropterin synthase activity of p-PTPS hexamer [cytosol]
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