DHNTP is dephosphorylated by PTPS to PTHP

Stable Identifier
R-HSA-1474184
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (Takikawa et al. 1986) catalyses the second step in BH4 biosynthesis, the dephosphorylation of DHNTP to 6-pyruvoyl-tetrahydropterin (PTHP). PTPS is believed to function as a homohexamer (Nar et al. 1994, Bürgisser et al. 1994) and has a requirement for Zn2+ (one Zn2+ ion bound per subunit) and Mg2+ ions for activity (Bürgisser et al. 1995). The phosphorylation of Ser-19 is an essential modification for enzyme activity (Scherer-Oppliger et al. 1999).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
6-pyruvoyltetrahydropterin synthase activity of p-PTPS hexamer [cytosol]
Physical Entity
Activity
Orthologous Events
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Created