6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (Takikawa et al. 1986) catalyses the second step in BH4 biosynthesis, the dephosphorylation of DHNTP to 6-pyruvoyl-tetrahydropterin (PTHP). PTPS is believed to function as a homohexamer (Nar et al. 1994, Bürgisser et al. 1994) and has a requirement for Zn2+ (one Zn2+ ion bound per subunit) and Mg2+ ions for activity (Bürgisser et al. 1995). The phosphorylation of Ser-19 is an essential modification for enzyme activity (Scherer-Oppliger et al. 1999).
Nar, H, Huber, R, Heizmann, CW, Thöny, B, Bürgisser, D
Bürgisser, DM, Thöny, B, Redweik, U, Hess, D, Heizmann, CW, Huber, R, Nar, H
Bürgisser, DM, Thöny, B, Redweik, U, Hunziker, P, Heizmann, CW, Blau, N
Scherer-Oppliger, T, Leimbacher, W, Blau, N, Thöny, B
Takikawa, S, Curtius, HC, Redweik, U, Leimbacher, W, Ghisla, S
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