Reactome | DHNTP is dephosphorylated by PTPS to PTHP

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DHNTP is dephosphorylated by PTPS to PTHP Show undefined attributes

catalystActivity	[CatalystActivity:10862341] 6-pyruvoyltetrahydropterin synthase activity of p-PTPS hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10862343
displayName	DHNTP is dephosphorylated by PTPS to PTHP
eventOf	[Pathway:R-DME-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Homo sapiens
input	[SimpleEntity:R-ALL-1474124] DHNTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DHNTP is dephosphorylated by PTPS to PTHP
output	[SimpleEntity:R-ALL-1475054] PPP [cytosol] [SimpleEntity:R-ALL-1474179] PTHP [cytosol]
precedingEvent	[Reaction:R-DME-1475422] PTPS is phosphorylated by cGMP-dependant protein kinase II - Drosophila melanogaster [Reaction:R-DME-1474146] GCH1 reduces GTP to dihydroneopterin triphosphate - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1474184
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(precedingEvent)	[Reaction:R-DME-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
(inferredTo)	[Reaction:R-HSA-1474184] DHNTP is dephosphorylated by PTPS to PTHP

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