Reactome | GCHFR binds to GCH1 and negatively regulates its activity

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GCHFR binds to GCH1 and negatively regulates its activity Show undefined attributes

authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
catalystActivity	[CatalystActivity:9959889] enzyme inhibitor activity of GCHFR pentamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1474141] Jassal, B, 2011-08-04
dbId	1474158
displayName	GCHFR binds to GCH1 and negatively regulates its activity
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
eventOf	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Homo sapiens
input	[Complex:R-HSA-1474144] GCH1 decamer [cytosol] 2 × [Complex:R-HSA-1474155] GCHFR pentamer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1474150] A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions [LiteratureReference:1474135] Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity [LiteratureReference:1474136] GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GCHFR binds to GCH1 and negatively regulates its activity
orthologousEvent	[Reaction:R-CEL-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Caenorhabditis elegans [Reaction:R-GGA-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Gallus gallus [Reaction:R-XTR-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Xenopus tropicalis [Reaction:R-DRE-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Danio rerio [Reaction:R-BTA-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Bos taurus [Reaction:R-CFA-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Canis familiaris [Reaction:R-RNO-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Rattus norvegicus [Reaction:R-MMU-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Mus musculus
output	[Complex:R-HSA-1474149] 2GCHFR:GCH1 [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23 [InstanceEdit:9963238] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1474158
summation	[Summation:1474142] High levels of the end product, BH4, negatively regulate GCH...
updateTrackers	[UpdateTracker:9964675] Update Tracker - [Reaction:1474158] GCHFR binds to GCH1 and negatively regulates its activity - v94:[modifyText, removeCatalystActivity]

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(updatedInstance)	[UpdateTracker:9964675] Update Tracker - [Reaction:1474158] GCHFR binds to GCH1 and negatively regulates its activity - v94:[modifyText, removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation