High levels of the end product, BH4, negatively regulate GCH...

created [InstanceEdit:1474141] Jassal, B, 2011-08-04
dbId 1474142
displayName High levels of the end product, BH4, negatively regulate GCH...
modified [InstanceEdit:9959890] D'Eustachio, Peter, 2025-07-02
schemaClass Summation
text High levels of the end product, BH4, negatively regulate GCH1 via GTP cyclohydrolase 1 feedback regulatory protein (GCHFR). BH4-dependant GCHFR in the form of a homopentamer complexes with the decameric GCH1 enzyme in the ratio 2:1 to inactivate it. L-phenylalanine reverses this inhibition. These regulatory steps control the biosynthesis of BH4. (Swick & Kapatos 2006, Chavan et al. 2006, Harada et al. 1993).
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