Reactome | GCHFR binds to GCH1 and negatively regulates its activity

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GCHFR binds to GCH1 and negatively regulates its activity Show undefined attributes

catalystActivity	[CatalystActivity:10595689] enzyme inhibitor activity of GCHFR pentamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10595691
displayName	GCHFR binds to GCH1 and negatively regulates its activity
eventOf	[Pathway:R-DRE-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1474158] GCHFR binds to GCH1 and negatively regulates its activity - Homo sapiens
input	[Complex:R-DRE-1474144] GCH1 decamer [cytosol] 2 × [Complex:R-DRE-1474155] GCHFR pentamer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GCHFR binds to GCH1 and negatively regulates its activity
output	[Complex:R-DRE-1474149] 2GCHFR:GCH1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1474158
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(inferredTo)	[Reaction:R-HSA-1474158] GCHFR binds to GCH1 and negatively regulates its activity

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