Reactome | Translocation of SLC2A4 (GLUT4) to the plasma membrane

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Translocation of SLC2A4 (GLUT4) to the plasma membrane Show undefined attributes

authored	[InstanceEdit:1428498] May, B, 2011-07-07
compartment	[Compartment:437051] cytoplasmic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:1445147] May, B, 2011-07-12
dbId	1445148
displayName	Translocation of SLC2A4 (GLUT4) to the plasma membrane
doi	10.3180/REACT_147867.1
edited	[InstanceEdit:1428498] May, B, 2011-07-07
eventOf	[Pathway:R-HSA-199991] Membrane Trafficking - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2316347] RAB4A:GTP binds KIF3 and activates KIF3 - Homo sapiens [BlackBoxEvent:R-HSA-1445144] p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) - Homo sapiens [Reaction:R-HSA-1445149] 14-3-3 binds p-5S,T642-AS160 (TBC1D4) - Homo sapiens [Reaction:R-HSA-1454699] AMPK-alpha2 phosphorylates TBC1D1 - Homo sapiens [Reaction:R-HSA-1454689] 14-3-3 Binds p-S237-TBC1D1 - Homo sapiens [Reaction:R-HSA-2255343] RAB8A,10,13,14 exchange GDP for GTP - Homo sapiens [Reaction:R-HSA-1445143] RAB8A,10,13,14 hydrolyze GTP - Homo sapiens [Reaction:R-HSA-1449597] p-AKT2 phosphorylates Myosin 5A - Homo sapiens [Reaction:R-HSA-1458463] p-AKT2 phosphorylates RGC2 - Homo sapiens [Reaction:R-HSA-2255342] RALA exchanges GDP for GTP - Homo sapiens [Reaction:R-HSA-2316349] RALA:GTP binds MYO1C:CALM1 and activates MYO1C - Homo sapiens [Reaction:R-HSA-1458485] RALA hydrolyzes GTP - Homo sapiens [Reaction:R-HSA-5260201] p-AKT2 phosphorylates C2CD5 - Homo sapiens [BlackBoxEvent:R-HSA-2316352] SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-1449574] SLC2A4 (GLUT4) vesicle fuses with the plasma membrane - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:1458653] Endocytosis, recycling, and regulated exocytosis of glucose transporter 4 [LiteratureReference:1458661] Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis [LiteratureReference:1458649] Biogenesis and regulation of insulin-responsive vesicles containing GLUT4 [LiteratureReference:1458642] The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets [LiteratureReference:1458646] Insulin action on glucose transporters through molecular switches, tracks and tethers [LiteratureReference:1458647] The sugar is sIRVed: sorting Glut4 and its fellow travelers [LiteratureReference:9605244] Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Translocation of SLC2A4 (GLUT4) to the plasma membrane
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2454132] Klip, Amira, 2012-08-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1445148
summation	[Summation:1458468] In adipocytes and myocytes insulin signaling causes intracel...
updateTrackers	[UpdateTracker:9777160] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v72:[updateContainedRLE] [UpdateTracker:9780391] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v63:[updateContainedRLE] [UpdateTracker:9779672] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v65:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9779759] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v64:[updateContainedRLE] [UpdateTracker:9786582] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v49:[updateContainedRLE] [UpdateTracker:9787061] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v46:[modifyText, updateContainedRLE] [UpdateTracker:9775496] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v78:[updateContainedRLE] [UpdateTracker:9784991] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v52:[addHasEvent] [UpdateTracker:9782071] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v59:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9777160] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v72:[updateContainedRLE]
[UpdateTracker:9780391] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v63:[updateContainedRLE]
[UpdateTracker:9779672] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v65:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9779759] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v64:[updateContainedRLE]
[UpdateTracker:9786582] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v49:[updateContainedRLE]
[UpdateTracker:9787061] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v46:[modifyText, updateContainedRLE]
[UpdateTracker:9775496] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v78:[updateContainedRLE]
[UpdateTracker:9784991] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v52:[addHasEvent]
[UpdateTracker:9782071] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v59:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-199991] Membrane Trafficking

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