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Schema
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FailedReaction
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Entries
F5 R534Q, A540V is not cleaved by activated protein C
Show undefined attributes
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authored
[InstanceEdit:9930429] Shamovsky, Veronica, 2024-12-03
catalystActivity
[CatalystActivity:141025] serine-type endopeptidase activity of Activated protein C:Protein S [plasma membrane]
category
transition
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:9930429] Shamovsky, Veronica, 2024-12-03
crossReference
[DatabaseIdentifier:12020815] Mondo:0002305
dbId
9930452
disease
[Disease:9668251] thrombophilia
displayName
F5 R534Q, A540V is not cleaved by activated protein C
edited
[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
entityFunctionalStatus
[EntityFunctionalStatus:9930431] loss_of_function of FV R534Q, FV A540V [extracellular region]
eventOf
[Pathway:R-HSA-9930449] Defective cleavage of FV variant at a.a.534 - Homo sapiens
input
[DefinedSet:R-HSA-9930490] FV R534Q, FV A540V [extracellular region]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9930447] Mutation in blood coagulation factor V associated with resistance to activated protein C
[LiteratureReference:9930475] Mechanisms of the factor V Leiden paradox
[LiteratureReference:9930462] Identification and functional characterization of a novel F5 mutation (Ala512Val, FVB onn ) associated with activated protein C resistance
maxDepth
1
modified
[InstanceEdit:9980332] Shamovsky, Veronica, 2026-01-27
name
F5 R534Q, A540V is not cleaved by activated protein C
Defective F5 is not cleaved at a.a.534 by activated protein C
normalReaction
[Reaction:R-HSA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form
releaseDate
2026-03-25
releaseStatus
NEW
reviewStatus
[ReviewStatus:9821383] three stars
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9930452
summation
[Summation:9930438] Under normal physiological conditions, activated protein C (...
Referrals
(hasEvent)
[Pathway:R-HSA-9930449] Defective cleavage of FV variant at a.a.534
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