Reactome | tissue factor (TF) + factor VII (F7) -> TF:F7 complex

Schema > Reaction > Entries

tissue factor (TF) + factor VII (F7) -> TF:F7 complex Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10739793
displayName	tissue factor (TF) + factor VII (F7) -> TF:F7 complex
eventOf	[Pathway:R-GGA-9769735] Initiation of coagulation cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9822513] TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst) - Gallus gallus
inferredFrom	[Reaction:R-HSA-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-140704] F3 [plasma membrane] [Complex:R-GGA-8959612] Factor VII:Ca2+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	tissue factor (TF) + factor VII (F7) -> TF:F7 complex formation of TF:F7 complex
output	[Complex:R-GGA-140775] TF:F7 [plasma membrane]
precedingEvent	[Reaction:R-GGA-140761] sequestered tissue factor -> tissue factor - Gallus gallus
regulatedBy	[PositiveRegulation:R-HSA-158645] Positive regulation by 'Ca2+ [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-140783
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-GGA-9822513] TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst)
(inferredTo)	[Reaction:R-HSA-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex

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