Phosphorylation of BIM by JNK

Stable Identifier
R-HSA-139918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
MAPK8 phosphorylates BCL2L11
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MAPK8 (JNK) phosphorylates BCL2L11 (BIM) on a DLC-binding motif (DKSTQTP), involved in dynein (DYNLL2 i.e. DLC1) binding and sequestration of BCL2L11 (BIM) to the cytoskeleton. Phosphorylated BCL2L11 dissociates from dynein. Three sites in BCL2L11 match the JNK consensus: S44, T56 and S58 in BCL2L11 isoform BimL (these residues correspond to S104, T116 and S118 in BCL2L11 isoform BimEL), and all sites appear to be phosphorylated by MAPK8 (JNK) both in vitro and in vivo (Lei and Davis 2003).

Literature References
PubMed ID Title Journal Year
12591950 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Lei, K, Davis, RJ

Proc Natl Acad Sci U S A 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of MAPK8 [cytosol]
Physical Entity
Activity
Orthologous Events
Created