PRLR is phosphorylated at Ser-349

Stable Identifier
R-HSA-1370505
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PRLR is phosphorylated at Ser-349
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The PRL responsiveness of target cells is negatively regulated by receptor internalization, ubiquitination and degradation, which limit the duration and intensity of receptor signaling (Djiane et al. 1981, 1982, Lu et al. 2002). The PRLR is phosphorylated on Ser-349 by an unidentified kinase (Li et al. 2006) enabling subsequent recruitment of the SCF beta-TrCP ubiquitin ligase complex (Li et al. 2004).
Literature References
PubMed ID Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Fuchs, SY, Spiegelman, VS, Tang, W, Li, Y, Kumar, KG

Mol Cell Biol 2004
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Orthologous Events
PRLR is phosphorylated at Ser-349 (Canis familiaris)
PRLR is phosphorylated at Ser-349 (Gallus gallus)
PRLR is phosphorylated at Ser-349 (Mus musculus)
PRLR is phosphorylated at Ser-349 (Rattus norvegicus)
PRLR is phosphorylated at Ser-349 (Sus scrofa)
PRLR is phosphorylated at Ser-349 (Xenopus tropicalis)
Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-07-04)
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