Reactome | Expression of DEC2 (BHLHE41, BHLHB3)

Schema > BlackBoxEvent > Entries

Expression of DEC2 (BHLHE41, BHLHB3) Show undefined attributes

authored	[InstanceEdit:879784] May, B, 2010-06-18
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:879757] May, B, 2010-06-23
dbId	879770
displayName	Expression of DEC2 (BHLHE41, BHLHB3)
edited	[InstanceEdit:879784] May, B, 2010-06-18
eventOf	[Pathway:R-HSA-1368108] BMAL1:CLOCK,NPAS2 activates circadian expression - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-879716] Expression of Dec2 (Bhlhe41, Bhlhb3) - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5641212] BHLHE41 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1368871] Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins [LiteratureReference:9909541] DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
maxDepth	1
modified	[InstanceEdit:9953423] May, Bruce, 2025-06-02
name	Expression of DEC2 (BHLHE41, BHLHB3)
output	[EntityWithAccessionedSequence:R-HSA-879703] BHLHE41 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5663105] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE41 (DEC2) gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-879843] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9909568] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]'
regulationReference	[RegulationReference:9642601] Positive gene expression regulation by 'p-BMAL1:p-CLOCK,NPAS2:BHLHE41 gene [nucleoplasm]' Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system [RegulationReference:9909559] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:9953422] Albrecht, Urs, 2025-03-07
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-879770
summation	[Summation:879751] The DEC2 (BHLHE41, BHLHB3) gene is transcribed to yield mRNA...
updateTrackers	[UpdateTracker:9785917] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v51:[addInput] [UpdateTracker:9953555] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v93:[removeLiteratureReference, removeRegulator] [UpdateTracker:9786974] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v46:[modifyText] [UpdateTracker:9785458] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v52:[add_removeRegulator] [UpdateTracker:9789249] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v38:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9785917] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v51:[addInput] [UpdateTracker:9953555] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v93:[removeLiteratureReference, removeRegulator] [UpdateTracker:9786974] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v46:[modifyText] [UpdateTracker:9785458] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v52:[add_removeRegulator] [UpdateTracker:9789249] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v38:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-1368108] BMAL1:CLOCK,NPAS2 activates circadian expression
(inferredTo)	[BlackBoxEvent:R-MMU-879716] Expression of Dec2 (Bhlhe41, Bhlhb3)

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