As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).
Gekakis, N, Staknis, D, Nguyen, HB, Davis, FC, Wilsbacher, LD, King, DP, Takahashi, JS, Weitz, CJ
Muñoz, E, Baler, R
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