Reactome | Mitochondrial iron-sulfur cluster biogenesis

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Mitochondrial iron-sulfur cluster biogenesis Show undefined attributes

authored	[InstanceEdit:2473458] Lill, R, 2012-09-24 [InstanceEdit:1362415] May, B, 2011-06-04
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:1362407] May, B, 2011-06-09
dbId	1362409
displayName	Mitochondrial iron-sulfur cluster biogenesis
doi	10.3180/REACT_150353.1
edited	[InstanceEdit:1362415] May, B, 2011-06-04
eventOf	[TopLevelPathway:R-HSA-1430728] Metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24332] iron-sulfur cluster assembly
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1362417] Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix - Homo sapiens [Reaction:R-HSA-1362416] Frataxin binds iron - Homo sapiens [Pathway:R-HSA-2395516] Electron transport from NADPH to Ferredoxin - Homo sapiens [BlackBoxEvent:R-HSA-1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - Homo sapiens [Reaction:R-HSA-8878815] Formation of 4Fe-4S cluster on ISCA1:ISCA2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:1481605] Frataxin and mitochondrial FeS cluster biogenesis [LiteratureReference:1481606] Iron-sulfur cluster biosynthesis [LiteratureReference:2399650] The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism [LiteratureReference:2466288] Function and biogenesis of iron-sulphur proteins [LiteratureReference:2466293] Iron-sulfur proteins in health and disease [LiteratureReference:2520956] Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease [LiteratureReference:1362364] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex [LiteratureReference:8878810] The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseases
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Mitochondrial iron-sulfur cluster biogenesis
orthologousEvent	[Pathway:R-MMU-1362409] Mitochondrial iron-sulfur cluster biogenesis - Mus musculus [Pathway:R-RNO-1362409] Mitochondrial iron-sulfur cluster biogenesis - Rattus norvegicus [Pathway:R-CFA-1362409] Mitochondrial iron-sulfur cluster biogenesis - Canis familiaris [Pathway:R-BTA-1362409] Mitochondrial iron-sulfur cluster biogenesis - Bos taurus [Pathway:R-SSC-1362409] Mitochondrial iron-sulfur cluster biogenesis - Sus scrofa [Pathway:R-XTR-1362409] Mitochondrial iron-sulfur cluster biogenesis - Xenopus tropicalis [Pathway:R-GGA-1362409] Mitochondrial iron-sulfur cluster biogenesis - Gallus gallus [Pathway:R-DME-1362409] Mitochondrial iron-sulfur cluster biogenesis - Drosophila melanogaster [Pathway:R-CEL-1362409] Mitochondrial iron-sulfur cluster biogenesis - Caenorhabditis elegans [Pathway:R-DDI-1362409] Mitochondrial iron-sulfur cluster biogenesis - Dictyostelium discoideum [Pathway:R-SPO-1362409] Mitochondrial iron-sulfur cluster biogenesis - Schizosaccharomyces pombe [Pathway:R-SCE-1362409] Mitochondrial iron-sulfur cluster biogenesis - Saccharomyces cerevisiae [Pathway:R-PFA-1362409] Mitochondrial iron-sulfur cluster biogenesis - Plasmodium falciparum [Pathway:R-DRE-1362409] Mitochondrial iron-sulfur cluster biogenesis - Danio rerio
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2520930] Rouault, Tracey A, 2012-10-11 [InstanceEdit:2520940] Tong, Wing-Hang, 2012-10-11 [InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1362409
summation	[Summation:1362316] Iron-sulfur (Fe-S) proteins are localized in the cytosol, nu...
updateTrackers	[UpdateTracker:9780305] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v63:[updateContainedRLE] [UpdateTracker:9782730] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v58:[addLiteratureReference, updateContainedRLE] [UpdateTracker:9777151] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v72:[updateContainedRLE] [UpdateTracker:9781774] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v60:[addHasEvent] [UpdateTracker:9787057] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v46:[modifyText]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-1430728] Metabolism
(hasEncapsulatedEvent)	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle [Pathway:R-HSA-9865881] Complex III assembly [Pathway:R-HSA-6799198] Complex I biogenesis [Pathway:R-HSA-9857492] Protein lipoylation
(updatedInstance)	[UpdateTracker:9780305] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v63:[updateContainedRLE] [UpdateTracker:9782730] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v58:[addLiteratureReference, updateContainedRLE] [UpdateTracker:9777151] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v72:[updateContainedRLE] [UpdateTracker:9781774] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v60:[addHasEvent] [UpdateTracker:9787057] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v46:[modifyText]

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